OKT3 monoclonal antibody reversal of acute renal allograft rejection unresponsive to conventional immunosuppressive treatments.
نویسندگان
چکیده
Immunobiology Division, Ortho Pharmaceutical Corporation, Raritan, NJ; Oregon Health Sciences University, Division of Nephrology, Portland, OR; St. Francis Regional Medical Center, Departli1ent of Surgery, Wichita, KS; Hopital Necker, Departement de Nephrologie, Paris, France; Johns Hopkins Hospital, Di vi si on of Transpl antation/Vascul ar Surgery, Baltimore, MD; Yale University School of Medicine, Department of Surgery, New Haven, CT; Ospedale Policlinico, Division Nefrologia, Milano, Italy; University of Pittsburgh, Department of Surgery, Pittsburgh, PA and New England Deaconess Hospital, Department of Surgery, Boston, MA
منابع مشابه
Use of OKT3 with cyclosporin and steroids for reversal of acute kidney and liver allograft rejection.
OKT3 monoclonal antibody therapy was added to preexisting baseline immunosuppressive treatment with ciclosporin and steroids to treat rejection in 52 recipients of cadaveric livers and 10 recipients of cadaveric kidneys. Rejection was controlled in 75% of patients treated, often after high-dose steroid therapy had failed. Rejection recurred during the 17-month follow-up period, after completion...
متن کاملTreatment of acute renal allograft rejection with OKT3 monoclonal antibody.
Eight cadaver donor renal allograft recipients, who had received azathioprine and prednisone from the day of transplantation, were treated with OKT3 monoclonal antibody (reactive with all mature peripheral blood T cells) at the time of diagnosis of acute rejection. In all cases, loss of essentially all detectable peripheral blood OKT3-reactive cells was noted within minutes after the initial 1-...
متن کاملInfections in pediatric liver recipients treated for acute rejection.
M URINE MONOCLONAL antibody OKTJ (orthoclone OKT3). is a powerful immunosuppressant and has been shown to be very effective in reversal of acute rejection following kidney, liver a nd heart transplants. I·) As with any kind of immunosuppression, one would expect that use of OKTJ might be associated with increased incidence of infections. However, there have been only a few detailed studies of i...
متن کاملCerebral complications of murine monoclonal CD3 antibody (OKT3): CT and MR findings.
Treatment of acute renal allograft rejection with mouse monoclonal antibody (OKT3) is associated with systemic and neurologic side effects. We describe cerebral abnormalities in a 13-year-old boy with steroid-resistant renal allograft rejection. After treatment with OKT3, an acute neurologic syndrome developed, including seizures, lethargy, and decreased mental function. CT and MR imaging revea...
متن کاملOKT3 in the reversal of acute hepatic allograft rejection.
OKT3 was an effective immunosuppressant agent in patients with acute cell-mediated allograft rejection that had not responded to initial steroid therapy. OKT3 was also valuable for treating patients with early hepatic graft dysfunction caused by other factors than rejection. In such recipients, the doses of CyA can be greatly reduced, allowing recovery of frequently damaged kidneys while mainta...
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ورودعنوان ژورنال:
- Progress in clinical and biological research
دوره 224 شماره
صفحات -
تاریخ انتشار 1986